Polycystic ovary syndrome (PCOS) is associated with irregular menstrual periods, infertility, obesity, diabetes, excess hair growth, acne, and other hormonal difficulties. Research shows that women with PCOS have an increased susceptibility to elevated insulin levels.
In a new study published six days ago in Cell Journal, researchers demonstrated that oral quercetin supplementation improves the metabolic features of PCOS patients by upregulating adiponectin and Amp-activated protein kinase (AMPK). Adiponectin signaling regulates fatty acid metabolism and glucose by activation of AMPK.
Pharmaceutical interventions provide some improvements but they do not correct many of the underlying factors and have side effects that may not be tolerated by patients. In addition, many PCOS patients are overweight and have dietary habits that exacerbate the condition.
This randomized clinical trial consisted of 84 patients with PCOS. They were randomly assigned to two groups. One group received 500 mg quercetin twice daily for 12 weeks and other group received a placebo. As a result, researchers demonstrated that oral quercetin supplementation significantly increased the expression of adiponectin receptors and AMPK. Quercetin supplementation enhanced AMPK level by 12.3% compared with the placebo group.
Other Nutrients to Consider to Support PCOS
Studies have shown that an inositol deficiency is common in women with PCOS. A distinctive characteristic feature of PCOS is a reduced ability to process, metabolize, and effectively use inositol from foods. As a result, the nutritional requirements of PCOS patients may not be met by a simple change in the diet and, thus, inositol should be viewed as a conditionally essential nutrient in these women.
Myo-inositol and D-chiro-inositol are both essential forms of inositol for patients with PCOS. The conversion of myo-inositol to D-chiro-inositol is of interest because errors here have been strongly involved in PCOS patients.
Strong evidence supports that the body makes D-chiro-inositol from myo-inositol and more evidence suggests that some people are less able to make this conversion than others. Along this spectrum, people who are completely unable to convert myo-inositol to D-chiro-inositol are only going to benefit from supplementation with D-chiro-inositol.
Other people who make the conversion, but with less than optimal efficiency, may benefit from large doses of myo-inositol. And, other individuals in between, might see the best results from a blend of the two. Since this conversion is impaired in individuals with PCOS, it is important to always include D-chiro-inositol with myo-inositol supplementation. D-chiro-inositol is the more potent form of inositol for supporting insulin resistance, however, myo-inositol is need for oocyte quality and maturation.
Therefore, supplementing with D-chiro-inositol alone cannot not fulfill myo-inositol’s roles that are specific and different from D-chiro-inositol, since it does not convert to myo-inositol.
Essential fatty acids are another consideration in PCOS. EFAs should be consumed in our diets for overall health, but most individuals with insulin resistance are deficient. Fish oils help to improve insulin sensitivity and reduce inflammation.
For more information on products listed in this article please log in to your Full Script account (Click here). Or create one (here) and have access to Dr. Aristotle's recommended products.
Source: M. Jurgelewicz, DC, DACBN, DCBCN, CNS, Rezvan N, Moini A, et al. Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovarian Syndrome Patients: A Randomized Placebo-Controlled Double-Blind Clinical Trial. Cell Journal. 2018 Jan;19(4):627-633. doi: 10.22074/cellj.2018.4577. Epub 2017 Nov 4.
It is rare if a pregnant woman does not encounter a certain amount of "morning sickness" throughout the term.
As any one who has ever experienced pregnancy can confirm, morning sickness leaves an expectant mother miserable for days, weeks or months, turning an otherwise joyful time into a period of misery.
Thankfully there is an integrative approach, when properly used, which produces a remarkable response.
It has been my personal clinical observation, that this system carries with it a success rate as high as 90 percent overall. You have everything to gain and nothing to lose by applying this method.
To get you started, begin by using these 3 acu-points with firm pressure for 30 seconds per area:
P 5 -- Jian Shi -- Intermediary -- four fingers above the palmar wrist crease.
P 6 -- Nei Guan -- Inner Gate -- three fingers above the palmar wrist crease.
LIV 3 -- Tai Chong -- Bigger Rushing -- between the large toe and second toe.
If your morning sickness is deep rooted and you still need additional assistance, let us know.
Health experts have been unable to agree on whether fluoride in the drinking water may be toxic to the developing human brain.
High levels of fluoride are known to cause neurotoxicity in adults, and negative impacts on memory and learning have been reported in rodent studies, but little is known about the substance’s impact on children’s neurodevelopment.
In a meta-analysis, researchers from Harvard School of Public Health (HSPH) and China Medical University in Shenyang for the first time combined 27 studies and found strong indications that fluoride may adversely affect cognitive development in children.
Based on the findings, the authors say that this risk should not be ignored, and that more research on fluoride’s impact on the developing brain is warranted.
“Fluoride seems to fit in with lead, mercury, and other poisons that cause chemical brain drain,” senior author Grandjean says. “The effect of each toxicant may seem small, but the combined damage on a population scale can be serious, especially because the brain power of the next generation is crucial to all of us.”
This study was published online in Environmental Health Perspectives on July 20, 2012.
Dr. Aristotle's Comment:
Toothpaste without fluoride is always an option.
One of my favorites is the PerioBiotic Toothpaste with probiotics in either spearmint of fennel flavors and no fluoride.
You can find it in your in your Healthwave/FullScript Account. (Click here)
If you don't have a Healthwave/Fullscript account, you can create one here and have access to Dr. Aristotle's recommended products.
Did You Know?
Are you or your neighbors spraying insecticides? Here are a few things to consider and what to do.
Newly published research in the Journal of Clinical Endocrinology & Metabolism shows that women’s reproductive health is vulnerable to chemicals commonly found in insecticides: DDT and phthalates.
Scientists attributed exposure to these chemicals with 145,000 cases of endometriosis and over 56,000 cases of uterine fibroids in European women.
Endometriosis is a condition where uterine tissue develops in other parts of the body, which can be quite painful.
Uterine fibroids are non-cancerous tumors that form in the uterus that cause fertility problems. Each of these conditions is increasingly common – the majority of women in the world are impacted by at least one of these disorders – and environmental factors seem to play a part in the growing rate.
The researchers estimate that these chemicals are costing the EU $150 billion because of these particular reproductive health issues. Once you begin to calculate doctor visits, medical procedures, fertility treatments the figure adds up quickly.
Keep in mind – that’s just looking at two of the issues. “Although these two gynecological conditions affect millions of women worldwide, this analysis only reflects the tip of the iceberg,” said Leonardo Trasande, a New York University professor who worked on this research. “A growing body of evidence suggests EDC exposure is linked to a broader range of female reproductive problems, including polycystic ovary syndrome, infertility and pregnancy complications.”
In other words, that EU$150 billion is probably a fraction of the cost if researchers were to have looked at other women’s health issues, too. Consider the non-sex specific health problems that have been connected to pesticides: cancer, asthma, hormone disruption, skin conditions, memory loss and loss of motor skills.
At a certain point, it becomes pointless to attach a price to use of insecticide because it’s clearly causing too much damage to excuse.
Though the study focused on women in Europe, DDT and phthalates are found in chemicals and even some plastics all over the world.
Dr. Aristotle Comment:
What can you do?
Nutrient support and regular detoxification with infrared sauna protocols will give you the best chance of keeping your body healthy. Order your comprehensive laboratory blood and urine analysis to get started.
Here is a link to a list of what your lab tests will be done.
Photo Credit: U.S. Department of Agriculture
Source: Kevin Mathews, Care2
Children whose mothers were exposed to flame retardants during pregnancy may have a lower IQ than their peers who did not experience prenatal exposure, a new study reports.
A hazardous class of flame retardant chemicals commonly found in furniture and household products damages children’s intelligence, resulting in loss of IQ points, according to a new study (August 2017) by UC San Francisco researchers. They found that every 10 fold increase of maternal flame retardant levels was associated with a drop of 3.7 IQ points in her child
We are exposed to a variety of chemicals each day. It’s nearly impossible to avoid them. If they accumulate in our body then we experience symptoms and eventually diagnosed with some disease. They find their way into the food chain, in particularly high concentration with products that are rich in fats such as fish, meat and milk. They also enter our systems as we breathe particles that have off-gassed from household furnishings.
In fact, today’s child at 6 years old already has chemical levels that it used to take us until our 40’s to accumulate.There are also strong links between fire retardants and the following conditions:
Accumulation of a lifetime of these toxins combined with others such as heavy metals can result in exhaustion, depression, weight gain, poor motivation, hair loss, and high cholesterol. It doesn’t end there….They can also cause problems; adrenal stress glands, low testosterone, reduced estrogen production, polycystic ovarian syndrome (POS), endometriosis, and cancer. Calcium channels can also blocked leading to high blood pressure, heart failure, and others.
The author Woodruff of the UC San Francisco study stated: “Many people are exposed to high levels of flame retardants (PBDEs) and the more PBDEs a pregnant woman is exposed to, the lower her child’s IQ,” And when the effects of PBDEs are combined with those of other toxic chemicals such as from building products or pesticides, the result is a serious chemical cocktail that our current environmental regulations simply don’t account for.”
The researchers also found some evidence of a link between PDBE exposures and attention deficit hyperactivity disorder (ADHD), but concluded that more studies are necessary to better characterize the relationship.
If you are planning a pregnancy, reduce the toxic load of your body including heavy metals and other toxins that have accumulated to reduce your baby’s exposure.
Review your current detoxification pathways and check if they are working properly through blood and urine testing.
Sweating is one proven mechanism for dumping stored environmental toxins Purchase an infrared sauna that uses “poplar wood” only. Call our office for a recommendation. I highly recommend using a sauna after your labs have been completed.
Eliminate trans fatty acids out of the diet, and restore missing essential fats, correct mineral deficiencies, like selenium, manganese, zinc and magnesium to facilitate safe detoxification.
Use cotton mattress covers and room air purifiers to help lower the toxins and avoid the memory foam pillows and beds due to out-gassing.
For more information on our pre-pregnancy programs call us at 310.734.0951
In MS, resulting nerve damage disrupts the communication between the brain and the body.
Multiple sclerosis causes many different symptoms, including vision loss, pain, fatigue, and impaired coordination. The symptoms, severity, and duration can vary from person to person.
According to a study published in the July 2017, issue of Neurology, mothers who breastfeed for a total of at least 15 months over one or more pregnancies may be less likely to develop multiple sclerosis (MS) compared with those who don’t breastfeed at all or do so for up to four months.
Early Chinese physicians discovered there is an energy network traversing just below the surface of the skin that communicates from the exterior to the internal organs and structures via over 1,000 "Acupoints" on the body.
This powerful energy works in harmony with the body's circulatory, nervous, muscular, digestive, genitourinary and all other systems of the body.
When this vital energy becomes blocked or weakened, an effect in a body system or anatomic location becomes evident. Stimulation of one or a combination of key "Acupoints" on the body may restore harmony to the affected area. This is why many treatments that only use structural techniques may not help you overcome pain.
Here are some points we use in our Beverly Hills clinic for shoulder pain that you can try at home.
Some programs will include laser and other non-invasive tools. I’ve included some images to help you locate the points.
To your continued healing!
by Dr. Aristotle Economou
Read Dr. Aristotle's new article "Bye Bye Headaches" in the recent issue of Westlake Malibu Magazine.
Click here to discover how to overcome headaches.
Taking aspirin to prevent stroke or heart attack is associated with a higher than expected risk for disabling or fatal bleeding in people aged 75 years and older, a new study shows in the June issue of The Lancet medical journal.
"We knew before that there was an increased risk of bleeding with aspirin in the elderly, but what we didn't know was how high that risk was and the consequences of those bleeds," senior author, Peter Rothwell, MD, John Radcliffe Hospital, University of Oxford, United Kingdom, explained to Medscape Medical News.
"There has been a sense that antiplatelets prevent important ischemic events, such as stroke and MI, and while we knew there is an increased risk of bleeding, this was seen as bit of a nuisance and not equivalent to the ischemic events. But our data shows that actually the bleeding is more likely to be disabling than the strokes in this age group so really needs to be taken more seriously."
Dr. Aristotle's note:
Be sure to take a look at the Blood/Urine Laboratory Testing to evaluate the biochemistry of your system. Your body may be lacking the targeted nutrients to support health and avoid chronic illness.
Here is a list of what is in our
Blood/Urine Laboratory Testing (click here).
Here’s The Number One Pollutant In Our Bodies!
They are found everywhere. It is difficult to completely avoid them. Plastics (or the chemical name, phthalates) are now considered the number one pollutant in the human body. They make products flexible, durable, and these chemicals are also in items you would not consider to be plastics, like pesticides, detergents, cosmetics, medications, or your shampoo.
You can live in the most pristine place on planet earth and still find animals polluted with plastics.
It is an interesting fact that plasticizers are over 10,000 to 1,000,000 times higher in our bodies than any other toxins that have been found in EPA studies.
Unfortunately once in the body, these plastics do enormous damage.
7 Ways Plastics Damage the Body
1. Brain Health
Phthalates damage the chemistry of fatty acids most importantly, the fatty acid, DHA (docosahexaenoic acid). This is the fundamental chemistry necessary for making every cell lining or membrane. These fatty acids are the foundation for brain health including memory and recall.
2. Indigestion, Depression, Heart Disease, Cancer, Diabetes, and Accelerated Aging
Phthalates can create a zinc deficiency which will compromise the metabolism of vitamins A and B-6. In turn this could lead to conditions such as indigestion, depression, heart disease, cancer, diabetes, and accelerated aging.
As a quick side note the combination of low zinc and low DHA can lead to chronic inflammation. Medical literature has clearly identified chronic inflammation as one of the most common underlying pathologies of most diseases leading to auto-immune diseases (rheumatoid arthritis, MS) to cancer and heart disease.
3. Diabetes, Insulin Resistance and Metabolic Syndrome X
Phthalates has been found to be responsible for damaging the pancreas leading to diabetes, insulin resistance and metabolic syndrome X.
4. Lower Sulfation
Phthalates has been found to lower sulfation. This means that you are no longer able to effectively detoxify like you should. This in turn can lead to a whole host of health challenges.
5. Hormone Function
Phthalates damage hormone function, especially thyroid and testosterone.
6. Cholesterol and “Happy Hormones”
Phthalates can poison the peroxisomes needed for the control of the chemistry of cholesterol. They can cause high cholesterol while at the same time keep cholesterol from forming the “happy hormones” (neurotransmitters) of the brain.
Phthalates can damage the body's ability to make catalase. Catalase is absolutely essential for devouring up the hydrogen peroxide that cancer cells make to allow them to metastasize or wildly spread throughout the body. Lack of catalase is a reason why many cancers briefly seem to be in remission after treatments, only to resurface months or years later with lethal consequences.
These are only 7 of the devastating effects of plastics in our bodies. Many diseases will never be cured until the phthalates are out.
Dr. Aristotle Economou